Reema Sen was born on 29th October 1981 in Kolkata, India. She has done her schooling in Kolkata and later moved to Mumbai with her family, where she began her career inmodelling.
Reema started her career as a model where she appeared for many advertising campaigns in Mumbai. Her first film was a low budget Telugu film, Chitram, in which her co-star was Uday Kiran. It was a love story where Reema returns to India from U.S.A along with her sister to get admitted in a college. Her next film was in Tamil called Minnale where Reema played the role of Reena, a college girl.
Later she considered entering the Hindi film industry but her movie Hum Ho Gaye Na was a super flop and she decided to continue her career in Tamil movies. After a long time she found success in a Tamil movie, Rendu, which was directed by Sundar C and her co-stars were Madhavan, Anushka Shetty, Bhagyaraj, and Vadivelu.