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Reema started her career as a model where she appeared for many advertising campaigns in Mumbai. Her first film was a low budget Telugu film, Chitram, in which her co-star was Uday Kiran. It was a love story where Reema returns to India from U.S.A along with her sister to get admitted in a college. Her next film was in Tamil called Minnale where Reema played the role of Reena, a college girl.
Later she considered entering the Hindi film industry but her movie Hum Ho Gaye Na was a super flop and she decided to continue her career in Tamil movies. After a long time she found success in a Tamil movie, Rendu, which was directed by Sundar C and her co-stars were Madhavan, Anushka Shetty, Bhagyaraj, and Vadivelu.